NR5A2 and hepatocellular carcinoma: For example, SUMOylation of the human LRH-1 K224, the lysine residue corresponding to mouse LRH-1 K289, binds to a transcriptional co-repressor complex consisting of NCOR1, HDAC3 and G Protein Pathway Suppressor 2 (GPS2) in hepatoma cells [76].