IPA of the 37 plasma-derived sEV protein features with ROC AUCs ≥ 0.70 revealed NKX3-1 (p = 1.4 × 10−9) as a top causal network, Cancer, Cell Death and Survival as a top disease function (p = 1.57 × 10−8) and AHR, VEGF, EGF, IRF1 and STAT3 as predicted significant upstream regulators (Data S12). Here, IRF1 is linked to cancer.