GNAQ and cardiac hypertrophy: In addition, mimicking pressure overload-induced hypertrophy in cardiomyocytes with overexpression of Gαq and homozygous knockout of ROCK1, a decreased expression of profibrotic factors as TGFβ2 and CTGF, as well as reduced left ventricular dilation and cardiomyocyte apoptosis, were found, but no prevention of cardiac hypertrophy was observed [11,65].