We divided five groups including normal group (Healthy mice), control group (NASH STAM mice), obeticholic acid group (NASH STAM mice + obeticholic acid), UNC1999 group (NASH STAM mice + UNC1999 EZH2 inhibitor), and EPZ6438 (NASH STAM mice + EPZ6438 EZH2 inhibitor). The gene discussed is EZH2; the disease is metabolic dysfunction-associated steatohepatitis.