Genovese et al. [48] observed that even application of a single dose of chemotherapeutics, such as DOX and paclitaxel targeting cancer cells lines or hematological malignancies and various solid tumors in vivo, led to amplification of chromosome region 7q21 containing gene ABCB1, subsequently resulting in overexpression of P-gp and other resistance-related proteins. Here, PGP is linked to cancer.