In addition, the results of Yuan et al. [31] demonstrated that cinobufagin, a substance isolated from the posterior auricular glands and skin of the Asiatic toad (Bufo gargarizans), affected modulation of P-gp activity in human P-gp-overexpressing colorectal carcinoma cells, including Caco-2/ADR, HCT116/L, and LoVo/ADR, which could potentially find it useful in combination with chemotherapeutic agents in colon cancer treatment. This evidence concerns the gene PGP and colonic neoplasm.