In light of this evidence, the negative correlations that we found between adiponectin and lipid profile, VAT, CPR, and TNF-α confirmed the profound involvement of adiponectin in many metabolic and inflammatory diseases and, in parallel, also confirmed the beneficial short-term effects of VLCKD intervention not only in the treatment of obesity but also in the establishment of obesity-correlated diseases. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.