In order to determine the in vivo effect of FOXF1 on the tumorigenic ability of lung cancer cells, the highly expressing FOXF1 cells (H441-FOXF1H and H1299-FOXF1H) were subcutaneously injected into non-obese diabetic/severe combined immunodeficiency (NOD-SCID) mice to observe the size of tumor formed. The gene discussed is FOXF1; the disease is neoplasm.