Enrichment of gene sets with differential expression in adherent JeKo-1 and REC-1 cells, identified by GSEA, as well as identification of several genes in this set that function downstream of the BCR (e.g., CD83, EGR3, DUSP2, NFKB1, and CCL4,Figure 2E,F and Table S1) led us to further investigate BCR signaling, which plays an essential role in the pathogenesis of MCL [43]. The gene discussed is BCR; the disease is mantle cell lymphoma.