However, the development of targeted therapy has emerged and several treatments have reached the first stages of clinical trials in cancer therapy, including inhibitors of histone methylation modifying enzymes such as disruptor of telomeric silencing 1-like (DOT1L) methyltransferases, enhancer of zeste homolog 2 (EZH2) methyltransferases, and lysine-specific demethylase 1 (LSD1) [28]. This evidence concerns the gene EZH2 and cancer.