To obtain a greater understanding of the role of JMJD10/MINA53 in gastric cancer, we have analyzed the JMJD10 molecular signature in gastric cancer using bioinformatics tools, compared the expression of JMJD10 protein expression in normal and tumor-paired gastric tumor samples, and used silencing and overexpression strategies in vitro in multiple gastric cancer cell lines. Here, RIOX2 is linked to gastric neoplasm.