BAMBI and scrapie: Protein BAMBI displayed an upregulation in the CSF of scrapie sheep at the clinical stage (2465 ± 174 pg/mL) compared to those at the preclinical stage (2103 ± 132 pg/mL, p < 0.01) and to control sheep (2114 ± 84 pg/mL, p < 0.01) (Figure 8A and Table S2).