Surprisingly, concentration of plasma-soluble P-selectin was lower in diabetic patients (3.03 (0.00; 6.50) ng/mL) compared to non-diabetic individuals (6.28 (0.65; 14.1) ng/mL) (median; IQR, p < 0.05, n = 36 (non-DM) and n = 39 (T2DM)). This evidence concerns the gene SELP and type 2 diabetes mellitus.