PROX1 and hepatocellular carcinoma: Thus, PROX1 acts as a tumor suppressor in hepatocellular carcinoma [8], esophageal cancer [9], pancreatic cancer [10], oral cancer [11], hematologic malignancy [12], sporadic breast cancer [13], carcinoma of the biliary system [14], and papillary thyroid cancer (PTC) [15].