Finally, a series of lymphatic factors, including PROX1, VEGFC, PDPN, VEGFR-3, SOX18 (SRY-Box transcription factor 18), and COUP-TFII (Nuclear receptor subfamily 2 group F member 2) can be expressed in tumoral cells and, consequently, control their properties, such as invasion, migration, proliferation, survival, epithelial to mesenchymal transition (EMT), and adhesion [30,31,32,33,34,35]. The gene discussed is PROX1; the disease is neoplasm.