In this scenario, many molecules associated with blood endothelial cells (such as CD44, Intercellular adhesion molecule 1; ICAM1, Vascular endothelial growth factor receptor 1; VEGFR-1 and Neutropilin-1) and LEC-specific proteins (including Podoplanin; PDPN, Lymphatic vessel endothelial hyaluronan receptor 1; LYVE-1, VEGFR-3, VEGFC, and PROX1) can be expressed in tumor cells and peri-/intra-tumoral vessels consequently regulating angiogenic potential of tumors. This evidence concerns the gene PROX1 and neoplasm.