In most part of oral cancers cases, critical genes, such as TP53, FAT1, NOTCH1, CASP8, and CDKN2A (p16INK4A) and PI3K mutations are found to be inactivated, leading to an overactivated cell cycle correlated to carcinogenetic process [147,153,154]. Here, NOTCH1 is linked to lip and oral cavity carcinoma.