IL16 and endometriosis: In addition, Matalliotakis et al. [66] demonstrated that SNP rs11556218 is associated with the development of endometriosis, probably as a result of the aberrant expression of interleukin-16 (IL-16), which activates T-lymphocytes, leading to the secretion of several pro-inflammatory cytokines, resulting in the survival of the ectopic endometrial tissue in the peritoneal cavity.