Raychaudhuri et al. analyzed the genome of 20,000 individuals, including over 5000 patients with anti-CCP positive RA, and identified gene variants contributing to RA risk, which encode two amino acids located in Positions 11 and 13 within HVR1 of the HLA-DRβ1 chain. Here, HLA-DRB1 is linked to rheumatoid arthritis.