Damaged protein, organelles, and insoluble aggregates are engulfed in autophagosomes, which are decorated with LC3 and p62 for maturation and subsequent lysosomal degradation, whereas dysfunction of autophagy results in the formation of insoluble cytosolic aggregates associated with p62 accumulation, contributing to the pathogenesis of neurodegenerative diseases and several lysosomal storage diseases [38,58]. The gene discussed is MAP1LC3A; the disease is lysosomal storage disease.