On the one hand, the secretion of IFN-γ increased remarkably with intensive training in peritoneal macrophages from trained rats and, interestingly, hesperidin supplementation prevented this effect in accordance with the inhibitory effect of hesperidin on IFN-γ previously described in an in vitro study using human mesenchymal stem cells [46] and in a mouse model of fulminant hepatitis [47]. The gene discussed is IFNG; the disease is Fulminant hepatitis.