(iii) As in Alzheimer’s disease, where oxidative stress is a recognized contributing factor in progression and pathogenesis of the disorder [48], in models of FXS amyloid beta (Aβ) expression is increased, probably as a consequence of FMRP-mediated dysregulation of amyloid precursor protein (APP) translation [173]. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.