The administration of resveratrol and caffeic acid to mutant ataxin 3-expressing human SK-N-SH neuroblastoma cells and to a drosophila model of SCA3 enhanced the NRF2 activity, up-regulating the expression of NQO1, catalase, HO-1, GPX, SOD, and GR and causing a consistent reduction of total and mitochondrial ROS [295]. Here, ATXN3 is linked to neuroblastoma.