This suggests ANGPTL7 protection extends to the MYOC risk group but the small counts preclude any definitive statement regarding interaction (P = 0.318, for interaction term in a logistic regression model)—given the limited number of double-carriers, larger case-control series are needed to refine our understanding as to whether ANGPTL7 p.Arg220Cys variant modifies the glaucoma risk conferred by p.Gln368Ter in MYOC. Here, ANGPTL7 is linked to glaucoma.