Because of the strong protective effect associated with the ANGPTL7 protein-altering variants (S9 Fig), further studies of ANGPTL7 inhibition and the specific action of these variant proteins should be useful in understanding the mechanism by which glaucoma protection occurs and whether this reveals a promising therapeutic opportunity similar to that which has been realized from the examples of PCSK9, APOC3 and cardiovascular disease [35–37]. Here, APOC3 is linked to cardiovascular disorder.