ACE2 expression is increased with the use of PPAR-γ agonists.26 PPAR-γ agonists, thiazolidinediones, attenuate the development of hypertension and improve endothelial dysfunction in angiotensin II-infused rats.43 These rats had decreased AT1 expression; therefore, the effects were most likely mediated through AT2 receptor activation.44 However, PPAR-γ agonists were shown to increase the risk of congestive heart failure and possibly myocardial infarction. This evidence concerns the gene AGTR1 and endothelial dysfunction.