Although controversial data exist in the literature, some variables of the R2CHA2DS2-VASc score (i.e., DM, coronary artery disease [CAD], PAD, LVEF, RBBB on baseline ECG, HF, or lower LVEF) and of the EuroSCORE II (i.e., extracardiac arteriopathy, diabetes on insulin, LVEF) were proposed to be related with mid-to-long-term mortality[17-22]. The gene discussed is INS; the disease is peripheral arterial disease.