CAT and Hepatic failure: In our study, interfering miR‐103a‐3p significantly reduced ROS content by upregulating expression of SOD1, CAT, and GSH in the LPS‐induced septic liver and in hepatocytes (AML12 and LO2 cells), implying that downregulation of miR‐103a‐3p might be a good choice to attenuate LPS‐induced liver failure by inhibiting ROS production.