In the first pedigree, the best candidate to explain the predisposition to eating disorders was a missense variant co‐segregating with the affected family members in the ESRRA (estrogen‐related receptor alpha) (OMIM *601998), while a potentially damaging mutation in the HDAC4 (histone deacetylase 4) (OMIM *605314) was reported in the second pedigree (Cui et al., 2013). The gene discussed is HDAC4; the disease is eating disorder.