This residue is found in the three haplotypes most associated with sarcoidosis (HLA‐DRB1*1101, HLA‐DRB1*1201, and HLA‐DRB1*1501) and might have a fundamental role in peptide binding and affect T‐cell recognition (Rossman et al., 2003). This evidence concerns the gene HLA-DRB1 and sarcoidosis.