This study revealed a novel mechanism by which the ZNRD1‐AS1‐144aa‐uORF regulated vasculogenic mimicry in the gliomas via the ZNRD1‐AS1/miR‐499a‐5p/ELF1/EMI1 pathway, providing a new therapeutic strategy for gliomas. The gene discussed is FBXO5; the disease is central nervous system cancer.