Our study first identified the endogenous expression of ZNRD1‐AS1‐144aa‐uORF, ZNRD1‐AS1, miR‐499a‐5p, ELF1 and EMI1 in tissues and cells of glioma and further studied the above‐mentioned intermolecular regulatory relationship, and the role and mechanism of biological behaviours such as VM formation in gliomas. The gene discussed is FBXO5; the disease is central nervous system cancer.