To verify whether ELF1 participates in the management of glioma cells VM via the ZNRD1‐AS1/miR‐499a‐5p pathway, and to detect the effect of ELF1 on the biological behaviour of glioma cells, cotransfection of miR‐499a‐5p cell lines with ELF1 was constructed. Here, ELF1 is linked to glioma.