Rescue with wild‐type METTL3, but not the catalytic mutant METTL3, restored the expression level of FOXO3 in METTL3‐knockdown HCC cells (Appendix Fig S4D and E) and sorafenib‐resistant HepG‐2 cells (Appendix Fig S4F), suggesting a role of m6A‐modification mediated by METTL3 in regulating FOXO3 expression level. This evidence concerns the gene METTL3 and hepatocellular carcinoma.