The functional components of the RNA methyltransferase complex include METTL3 (methyltransferase‐like 3), METTL14 (methyltransferase‐like 14), and WTAP (Wilms tumor 1‐associated protein), while the RNA demethylases include FTO (fat mass and obesity‐associated protein) and ALKBH5 (a‐ketoglutarate‐dependent dioxygenase alkB homolog 5). This evidence concerns the gene WTAP and obesity due to melanocortin 4 receptor deficiency.