Notably, depletion of METTL3 by using in vivo‐optimized RNAi significantly rescued the xenograft tumor growth compared with the control under sorafenib treatment (Fig 7B–D and I), which showed increased proliferation, autophagy, and angiogenesis (Fig 7E) as indicated by Ki67 (Fig 7F), LC3‐B (Fig 7G), and VEGF‐A (Fig 7H), respectively. The gene discussed is METTL3; the disease is neoplasm.