Figure 8B,C illustrated that the five genes were changed in 82 (27%) of the 308 cases/patients (310 in total); EDNRB, EPB41L3, and ID4 showed most diverse alterations, including amplification, missense mutation etc. The relevance between mRNA and DNA methylation of the five genes in the TCGA CESC patients was demonstrated in Figure 8D. We found that methylation negatively regulated the mRNA expression of the five genes. The gene discussed is EDNRB; the disease is cervical squamous cell carcinoma.