Recently, other groups identified the expression of ILT4 and its mouse homologue paired Ig-like receptor (PIR-B) in immunocytes of the tumor microenvironment (TME) including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and hemopoietic stem cells (HSCs) [15, 16]. This evidence concerns the gene LILRB2 and neoplasm.