HPSE and urinary bladder cancer: Li et al 11 found a very low expression level of circHIPK3 in bladder cancer (BC) samples compared with that in normal tissues; over-expression of circHIPK3 could inhibit migration, invasion and angiogenesis of BC cell lines in vitro by abundantly sponging miR-558 and further suppressing the expression of heparanase (HPSE).