The result showed that the expression of MTHFD1L in colon cancer tissues was not significantly correlated with patient's gender, age, tumor size, but positively correlated with the degree of tumor differentiation, TMN classification, tumor invasion depth, lymph node metastasis, and distant metastasis (p<0.05 for all; table 1). The gene discussed is MTHFD1L; the disease is malignant colon neoplasm.