Importantly, AKT is the common point of convergence of multiple signaling axis such as IL8/AKT 62, ERK/AKT 63, PI3K/ AKT/Bcl-2 64, FAK/Akt/JNK 65, PTEN/Akt/mTOR 61, 66, 67, etc. Many genes and non-coding RNAs can associate with AKT along with its crosstalk to regulate radioresistance of NPC. The gene discussed is AKT1; the disease is nasopharyngeal carcinoma.