Genomic instability is associated strongly with tumor formation, notably, LMP1 may repress DNA repair and contribute to genomic instability in human epithelial cells by triggering the PI3K/Akt pathway to inactivate the FOXO3a (The Forkhead box class O) and decrease DDB1 (DNA damage-binding protein 1) 117. Here, DDB1 is linked to neoplasm.