On the one hand, LIF activates mTORC1/p70S6K signaling via LIF receptor, leading to increased tumor growth; LIF-mediated radioresistance may result from the inhibition of DNA damage responses (DDR) signaling; EBV-encoded LMP1 can induce LIF expression through NF-κB activation in NPC cells. This evidence concerns the gene PDLIM7 and neoplasm.