HOXB13 and posterior cortical atrophy: Previous studies also have revealed different genetic alterations in young PCa, such as a greater number of single nucleotide polymorphism in the germinal DNA 6-8, different expressed genes involved in the inflammatory and immune-related pathways (CTL4, IDO1/TDO2) 9, and gene mutations in BRCA 1 and 2, and HOXB13 5.