Clinically, increase in serum immunoglobulins are observed in specific hapatobiliary diseases such as autoimmune hepatitis (elevated IgG), primary biliary cirrhosis (elevated IgM) and alcoholic liver disease (elevated IgA), Immunoglobulin G4-related sclerosing cholangitis (elevated IgG) 36. This evidence concerns the gene CD40LG and autoimmune hepatitis.