Down-regulation of Akt-GSK3β-FBW7 signaling axis promoted the destabilization of c-Myc. In order to further demonstrate that c-Myc is essential for HK2 expression in GBM cells, the c-Myc knockdown stable cell lines in U87, T98G, and LN229 were constructed. Here, FBXW7 is linked to glioblastoma.