The expression changes of DVL mRNAs available in the ICGC data base 25, which includes results from 981 HNSCC tumors are similar to the data reported by Li et al. In line with this, we detected down-regulation of DVL2 mRNA in HNSCC tumor tissue samples compared to their non-cancerous counterparts. Here, DVL2 is linked to head and neck squamous cell carcinoma.