Subsequently, the multivariate analyses further revealed that the TRIM4 level (hazard ratio, 0.550; 95% CI, 0.321-0.944; p=0.030), tumour diameter (hazard ratio, 2.191; 95% CI, 1.264-3.798; p<0.01), and vascular invasion (hazard ratio, 2.249; 95% CI, 1.322-3.826; p<0.01) were independent predictive factors for OS of HCC patients (Table 3). This evidence concerns the gene TRIM4 and neoplasm.