For example, TRIM29, which appears to be localized primarily to the cytoplasm, can bind to and stabilize Dvl-2; this interaction results in the release of β-catenin from the destruction complex and the activation of downstream β-catenin/TCF-regulated target genes and subsequently contributes to the development of pancreatic cancer 28. Here, HNF4A is linked to familial pancreatic carcinoma.