For example, TRIM29, which appears to be localized primarily to the cytoplasm, can bind to and stabilize Dvl-2; this interaction results in the release of β-catenin from the destruction complex and the activation of downstream β-catenin/TCF-regulated target genes and subsequently contributes to the development of pancreatic cancer 28. The gene discussed is HNF4A; the disease is pancreatic neoplasm.