The serum CRP levels increased by about 6 folds in SCE buffaloes than control that could be attributed to the promotion of mononuclear cells in response to uterine infection to produce their cytokines TNF-α and IL-8 which subsequently stimulated the emission of CRP from liver into blood stream (Kaya et al., 2016; Lee et al., 2003). Here, CXCL8 is linked to endometritis.