At present, DPP-4 inhibitors have been recommended by IDF Global Guidelines for the Management of Senile Type 2 Diabetes and China Expert Consensus on Diagnosis and Treatment Measures of Senile Diabetes as first-line alternative drugs for the treatment of senile diabetes mellitus, and are widely used in elderly patients with type 2 diabetes mellitus [3]. This evidence concerns the gene DPP4 and type 2 diabetes mellitus.