HIF1A and esophageal squamous cell carcinoma: Interestingly, hypoxic stress induces the cytoplasm-to-nucleus translocation of eIF5A2 protein in esophageal squamous cell carcinoma (ESCC) cell lines, and eIF5A2 in the nucleus, promotes the transcription of HIF1α by binding to the promoter region of HIF1α [26].