In glioblastomas, the relevant investigation reported an up-regulation of DHS, DOHH, and EIF5A1 in glioblastoma patient samples with different grades, and both inhibition of hypusination by GC7 or stable knockdown of DHS and EIF5A1 impaired the proliferation of glioma cells in vitro [69]. Here, EIF5A is linked to central nervous system cancer.