In human melanoma, both the cytoplasmic and nuclear eIF5A2 protein levels are inversely correlated with patient survival, and patients with positive cytoplasmic and nuclear eIF5A2 staining showed the poorest disease-specific 5-year survival rates compared with patients with negative staining in both the cytoplasm and nucleus and patients with only positive stain in either the cytoplasm or nucleus [92, 93]. The gene discussed is EIF5A2; the disease is melanoma.