In epithelial ovarian cancer (EOC), both western blotting and IHC staining assay revealed that eIF5A1 protein expression was upregulated compared with the normal ovarian tissues, and the results of correlation regression analysis and Kaplan–Meier analysis indicated that higher eIF5A1 protein levels are correlated with EOC progression and poor prognosis. The gene discussed is EIF5A; the disease is ovarian carcinoma.