MSH6 and cancer: NUP62 can promote cell proliferation in squamous cell carcinoma [29], EHMT2 contributes to tumor aggressiveness [30], RANBP1 affects the mitotic microtubule activity and Taxol sensitivity of cancer cells [31], and MSH6 is associated with a poor prognosis in several types of cancer [32], while FHL2 is a negative regulator of TGF-β1 transcription in the liver and plays a suppressive role in HCC metastasis [33, 34].