CSF1R and early-onset autosomal dominant Alzheimer disease: In addition, it is important to understand the systemic effects of CSF1R inhibition on macrophages, as inhibition of CSF1R is a clinical strategy for the intentional depletion of macrophages in various disease contexts, including Alzheimer’s disease, brain injury and cancer (Edwards et al., 2019; Lloyd et al., 2019; Tap et al., 2015; Webb et al., 2018).