Moreover, studies using a SNAP-25 mutant mouse demonstrated anxiety-related behavior (Kataoka et al. 2011), indicating that alterations in SNAP-25 gene structure, expression, and/or function may result in changes in the regulation of emotional behavior and the development of symptoms similar to those observed in neuropsychiatric and neurological disorders (Corradini et al. 2009). Here, SNAP25 is linked to nervous system disorder.