SNAP25 and major depressive disorder: Genetic studies confirmed the association of Snap25 with ADHD, schizophrenia, and major depressive disorder (Houenou et al. 2017; Wang et al. 2018; Wang et al. 2015); however, apart from the report on the relationship between the Snap25 polymorphism and ASD in the Iranian population (Safari et al. 2017), the direct association between SNAP-25 and ASD has never been shown in humans.