It has been shown that monocytes from patients with CF have increased expression of MMP9, associated with increased intracellular Ca2+ when compared with non-CF monocytes [180, 181]; remarkably, monocytes with from CF patients treated with Ivacaftor/Lumacaftor showed reduced intracellular Ca2+ levels [180]. The gene discussed is MMP9; the disease is cystic fibrosis.