SLC7A5 and neoplasm: In cells treated with 5 μM DFO, LAT1 expression was restored in all cell lines treated with siRNA (P = 0.102 for T98G cells, P = 0.004 for HSC-3 cells, P = 0.030 for MCF-7 cells) (Fig. 6D–F), revealing that HIF-1α suppresses LAT1 expression in hypoxic tumor cells.