IDH2 and esophageal squamous cell carcinoma: In our previous study, we identified IDH2 as a valuable prognostic marker for ESCC patients who received only surgery.15 Although several in vitro studies show that mediating IDH expression could affect the response to γ-rays in human monocytes, glioma cells, and mouse embryonic fibroblasts,16–18 animal experiments and studies on the clinical significance remain inadequate.