AKT, as an important survival kinase, has been proved to play a key role in radioresistance in several neoplasms.34–36 Our previous study demonstrated that AKT phosphorylation contributed to radioresistance of ESCC cells.20 In addition, AKT phosphorylation is responsive to oxidative stress.37 In this study, inhibition of AKT phosphorylation was identified as an underlying molecular occurrence after mediating IDH2 activity. Here, AKT1 is linked to esophageal squamous cell carcinoma.