In addition to the WRN−/− and BLM−/− ESC lines generated using CRISPR/Cas9, we also attempted shRNA-mediated WRN or BLM knockdown in primary adipose-derived stem cells and the Simpson-Golabi-Behmel Syndrome (SGBS) human preadipocyte line. The gene discussed is BLM; the disease is Simpson-Golabi-Behmel syndrome.