Concurrently, the diameters and volumes of left ventricle (LV) became enlarged with thinner anterior and posterior walls in the PKBαf/f;MCM;PKBβ−/− mice under both systolic and diastolic conditions (Fig. 1d–e, Supplementary Fig. 1g–l), suggesting that deletion of PKBα/β in adult hearts causes dilated cardiomyopathy. Here, PPIB is linked to dilated cardiomyopathy.