Then, we focused on the differentially expressed genes in PI3K/Akt signaling pathway (Fig. 3c) and examined the expression of PI3Kγ (also called PIK3CG, gene ID: 5294; one of the most important genes in PI3K/Akt signaling) in tumor cells and in normal ARPE19 cells. This evidence concerns the gene AKT1 and neoplasm.