Indeed, as chemokine (C-C motif) receptor 8 (CCR8) was identified as an EV receptor at the surface of GBM cells, via glycans exposed on EVs and the soluble chemokine ligand C-C Motif Chemokine Ligand 8 (CCL18), inhibition of CRR8 using small molecule R243 was demonstrated to interrupt the uptake of EVs by GBM cells, thereby sensitising GBM cells to TMZ [85]. This evidence concerns the gene CCL18 and glioblastoma.