In addition, hypoxic GBM-derived EVs containing miR-1246 were demonstrated to facilitate the formation of an immunosuppressive GBM TME through inducing M2 macrophage polarisation in targeting telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP), thereby activating the signal transducer and activator of transcription 3 (STAT3) pathway and inhibiting the nuclear factor kappa B (NF-κB) pathway [42]. The gene discussed is STAT3; the disease is glioblastoma.