EV-based delivery of long intervening/intergenic non-coding RNA POU3F3 (lincPOU3F3) as well as long non-coding RNA CCAT2 (linc-CCAT2) to ECs has also been observed to trigger angiogenesis in the GBM TME in vitro and in vivo [26, 27]. Here, CCAT2 is linked to glioblastoma.