The AD (n = 42) and control (n = 39) groups had similar demographic characteristics but significantly different clinical features, based on the Mini-Mental State Examination (MMSE), Clinical Dementia Rating Scale (CDR), CDR sum-of-boxes (SOB) scores, number of APOE ε4 alleles, medial temporal atrophy grades, and CSF Aβ42, tTau, and pTau181 levels (Table 1). This evidence concerns the gene APOE and Alzheimer disease.