Consistent with the results of SWATH-MS, the protein expression of neurosecretory protein VGF, chromogranin-A (CgA), secretogranin-1 (SgI), and opioid-binding protein/cell adhesion (OPCML) decreased in AD samples, whereas that of 14-3-3 protein zeta/delta (14-3-3ζ) increased (Fig. 1c). This evidence concerns the gene CHGB and Alzheimer disease.