Therefore, in this study we aim to establish a quantitative treatment-biomarker-survival modelling framework using nonlinear mixed effects PKPD modelling to link the survival of advanced melanoma patients with LDH, MIA and/or S100B protein kinetics following IFN-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha 2b$$\end{document}α2b administration. Here, IFNA1 is linked to melanoma.